Investigação da atividade entinociceptiva e anti-inflamatória do noni em ratos wistar.

Abstract

The Morinda citrifolia is a species widely used as a therapeutic tool for the treatment of various diseases. To this plant has been assigned several pharmacological activities such as: antioxidant, antitumor, anti-inflammatory, antimicrobial, among others. Although many of the described activities have been observed in different parts of the plant, its fruit, popularly known as noni, has been highlighted, because they are taken as having several nutraceutical properties. This study aimed to investigate the antinociceptive and anti-inflammatory activity of noni in wistar rats. For this observation was performed the formalin test and measurement of paw edema. The animals were divided into four groups: experimental group and the control group which received the aqueous noni extract and distilled water by the oral route, respectively, for 20 days; and the standards groups for the test which received morphine and indomethacin intraperitoneally only on the day of testing. The results were analyzed in Graph Pad Prism program and were considered significant when p <0,05. In the formalin test treatment with Noni extract at a dose of 75 mg/kg significantly reduced (p <0.01) at 1st phase (74.3%) and the 2nd phase (44.9%). In the evaluation of paw edema was no significant difference between groups. Therefore, this study demonstrated that noni presented antinociceptive and inflammatory significant activities, suggesting an involvement of the opioid system in its mechanism of action, and did not showed anti-endema significant activity through the paw edema.