LOPES, Y. A. C. F.; http://lattes.cnpq.br/9805139456572530; LOPES, Ysabel Arianne Cordeiro Ferreira.
Abstract:
Tetracyclines are produced by pharmaceutical agents and which are available in the market in various dosage forms. The objective of this study was, assays were performed, physico-chemical medium weight, disintegration e assay physicochemical and microbiological. Were analyzed samples of tetracycline capsules. All assays for all samples were preceded by the methods recommended by the Brazilian Pharmacopoeia (2010). Samples, all were approved. In the assay medium weight average sample weight A was 0.5323g and the sample B media mass was 0.5398g. In the disintegration test samples disintegrated in 13 minutes time for the sample A and 12 minutes for sample B. The determination of power through the agar diffusion assay employing diving Staphylococcus aureus as a biological reagent, power resulted in the two samples below the limit specified 90 to 125% the labeled amount, with the result 84 and 86%. Comparative study of this method with the method of determination by spectrophotometry - UV was performed. The results presented for determining the content of tetracycline 99,84% for comp A and 109,56% for comp B. In comparing the two method satisfactory result was observed for dosing by esctrofotômetria-UV, and unsatisfactory for the microbiological assay, by presenting results outside the pharmacopoeial parameters. From these results it can be concluded then, that for the physico-chemical quality parameters regarding the tests of average weight, disintegration and spectrophotometric-UV assay for all samples were within the limits of acceptability for the assay by agar diffusion results obtained were outside the limits in pharmacopoeia.