Avaliação da eficácia de conservantes em emulsão lanette®.

Abstract

It is perceptible growth of manipulated products market, it fits on the pharmacies to ensure total quality and safety regarding these products use. One of the mores dispensed preparations are the emulsions for dermatologic and aesthetic purposes, characterized as galenic base and designed to serve a wide variety of drugs. Composed by two immiscible liquids, an oil phase and one aqueous phase so that the mixture of lipids and water easily promotes various microorganisms.growth. As a consequence the inclusion of preservatives in the formulation is an essential factor in ensuring the preparations microbiological quality and stability preventing microbial proliferation. The aim of this study was to test the preservative system (methyl and propyl) efficacy in the lanette® wax based emulsion manipulated in Manuel Casado de Almeida pharmacy school (UFCG/Cuité – PB). This test consisted of contaminating the sample with separate inoculants Esherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans , Aspergillus niger and determine the viable microorganisms number by the method of pour plate at 0, 7, 14, 21, 28 days. Taking as a basis the Brazilian Pharmacopoeia V criteria, the results showed that the preservative system was effective in only three challenging microorganisms, gram-negative bacteria E. coli and P. aeruginosa were not inhibited as expected. Thus, further studies aimed at investigating the inefficiency causes by the preservative system is suggested, by evaluating the composition of the formulation and the methods of manipulation.