Avaliação de potenciais interações medicamentosas em prescrições de pacientes internados no Hospital Universitário Alcides Carneiro.

Abstract

Drug interactions occur when the effect of one drug is altered by previous or simultaneous use of another drug, food or drink. Are classified in moderate, mild and severe according to their severity and side effects. The mechanisms involved in interactions are classified according to the stage pharmacological occurring in pharmaceuticals, pharmacokinetics and pharmacodynamics. Polypharmacy, defined as the use of multiple drugs simultaneously, is the most important drug-drug interaction risk factor. In a hospital setting, the patient makes use of approximately six drugs, which increases the probability of an interaction. These interactions can result in ineffective therapy and increase the length of stay of patients. Based on this context, the present study aimed to investigate the occurrence of potential drug interactions in prescriptions for inpatients at the University Hospital Alcides Carneiro (HUAC). A descriptive study was conducted using quantitative and qualitative approach. Data collection was performed in the central pharmacy of HUAC, from the requirements of patients admitted in the units of female and male medical clinic during the period of two months. Of the 169 prescriptions analyzed 108 (63.9%) showed interaction. Most interactions found possessed pharmacodynamic mechanism of action, moderate severity, unspecified onset of action and good documentation. Polypharmacy was a determining factor for the occurrence of interactions. Ten drugs were responsible for 97, 98% of interactions. From the results obtained it is possible to assess risks involving the prescriptions. Many interactions have their use justified, leaving the pharmacist and the multidisciplinary team the benefit / risk and, if necessary, the therapeutic management review.