MAIA, P. C. G. G. S.; http://lattes.cnpq.br/1995785733516214; MAIA, Paula Christianne Gomes Gouveia Souto.
Resumo:
The study of drug controlled release system is constantly growing, it aims to improve
and extend the control of drug administration. Oral insulin is a dream of patients and
a challenge for scientists. For patients, it's not just pain relief applying multiple
injections, but also the protection of beta cells of the pancreas. Chitosan, a
biomaterial is considered non-toxic, non-allergenic, biodegradable, biofunctional,
biocompatible and their biological activities include the antioxidant action,
antimicrobial, analgesic, acceleration of wound healing, anti-inflammatory as well as
being widely studied as polymer matrix systems controlled drug release. Gelatin turn
is being widely used in the pharmaceutical field for the purpose of favoring the
system swelling and consequently accelerate the release process. Thus, this study
aimed to develop chitosan membranes, gelatin and insulin for use in controlled
release system of drugs. The developed membranes were characterized by powder
Diffraction X-ray (XRD), spectroscopy in the infrared region with a Fourier transform
(FTIR) analysis, Scanning Electron Microscopy (SEM) with Energy Dispersive
Spectroscopy X-ray (EDS) and Microscopy optical (MO). In XRD technique we found
that what was no significant change in the crystallinity of the membranes. With FTIR
technique found that gelatin, insulin and sodium tripolyphosphate did not affect the
surface functional groups of chitosan, thereby maintaining the properties thereof. The
EDS was possible to detect the characteristic chemical elements of the material. It
was possible to see, through the techniques of OM and SEM, change in morphology
of the membrane containing insulin, gelatin and sodium tripolyphosphate compared
to pure chitosan. Based on the results it can be concluded that insulin was
encapsulated by chitosan and the presence of the gelatin influence the size and
shape of the pores of the membranes and neutralization with NaOH decreased the
amount of agglomerates on the surfaces of scaffolds crosslinked with sodium
tripolyphosphate.