Leishmaniose visceral e coinfecções em seres humanos e animais domésticos: uma revisão de literatura

Abstract

The proposed study aimed to describe the coinfections between Leishmania infantum and other microorganisms, affecting both humans and domestic and wild mammals. Visceral leishmaniasis is a serious, systemic disease that can be potentially fatal if not treated properly. In addition to the public health issues related to visceral leishmaniasis, recent research demonstrates the occurrence of coinfections between Leishmania spp. and other pathogens in humans and animals, presenting significant implications for the health of affected individuals. The interaction between microorganisms can result in changes in the immune response, disease progression, and the effectiveness of available treatments. Maintaining a balance in immune responses is essential for the effective control of pathogens. In the case of coinfections, the immune systems of domestic animals and humans may become overloaded, leading to exaggerated inflammatory responses and damage to tissues and organs. This condition can allow uncontrolled replication and spread of microorganisms, increasing the risk of complications and compromising the organism. In this context, understanding the interactions between leishmaniasis and other parasitic infections is of utmost importance for the control and proper management of these complex, multifactorial diseases.